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5 Comments

  1. 1

    Margaret Boyd

    Simon says
    “The Dow chemical company which makes PG advises “Dow does not support or recommend the use of Dow’s glycols where breathing or human eye contact with the spray mists of these products is likely”

    So the use of propylene glycol in nicorette quickmist is ok then because big pharma says it’s ok ?
    Link
    http://www.medicines.org.au/files/pcpnicqm.pdf
    Quote
    “DESCRIPTION

    NICORETTE® QuickMist contains nicotine. 0.07 mL contains 1mg nicotine, corresponding to 1 mg nicotine/spray dose.

    NICORETTE® QuickMist in addition to the active contains: propylene glycol, anhydrous ethanol, trometamol, poloxamer 407, glycerol, sodium hydrogen carbonate, levomenthol, mint flavour, cooling flavour, sucralose, acesulfame potassium, hydrochloric acid and purified water.

    The mouth spray contains small amounts of ethanol (alcohol), less than 100mg per spray. “

    Reply
    1. 1.1

      Simon Chapman

      Margaret, Big Pharma doesn’t say it’s OK. The TGA reviewed the evidence on safety (whare are the risks of using the standardised product as formulated under normal conditions of use) and efficacy (does it help smokers quit) and passed it. We don’t know how much PG vapers inhale with their (average) 200 inhalations/day (up to 600) but looking a chat lines about inhalable NRT, comments about using it about 4 times a day can be found. Likely to be rather different? I’m not a huge fan of the data on efficacy for NRT (see https://theconversation.com/drugs-gums-or-patches-wont-increase-your-chances-of-quitting-89767) so don;t look to me to defend that. And the US National Academies of Science, Engineering and Medicine’s 2018 report on ecigs described the evidence about ecigs being good fr cessation as:

      Conclusion 17-2. There is moderate evidence from randomized controlled trials that e-cigarettes with nicotine are more effective than e-cigarettes without nicotine for smoking cessation.
      Conclusion 17-4. While the overall evidence from observational trials is mixed, there is
      moderate evidence from observational studies that more frequent use of e-cigarettes is associated with increased likelihood of cessation. https://www.nap.edu/resource/24952/012318ecigaretteConclusionsbyEvidence.pdf.

      “Moderate evidence” is below both conclusive and substantial evidence.

      Reply
      1. 1.1.1

        Margaret Boyd

        Simon
        I was under the impression that the FDA is considering Vaping products as reduced risk products as compared to known toxic smoke from cigarettes

        I also believe the NASEM Report was to identify areas that need further research that is why they say low, medium high etc

        Quote “With support from the Center for Tobacco Products of the Food and Drug Administration (FDA), the National Academies of Sciences, Engineering, and Medicine convened an expert committee to conduct a critical, objective review of the scientific evidence about e-cigarettes and health. The resulting report, Public Health Consequences of E-Cigarettes, provides an overview of the evidence,
        recommends ways to improve the research, and highlights gaps that are priority focus areas for future work. ”

        NASEM also say
        “Overall, e-cigarette aerosol contains fewer numbers and lower levels of toxicants than smoke from combustible tobacco cigarettes.
        &
        Across a range of studies and outcomes, e-cigarettes appear to pose less risk to an indi- vidual than combustible tobacco cigarettes. ”
        Link
        https://www.nap.edu/resource/24952/012318ecigaretteHighlights.pdf

        Reply
        1. 1.1.1.1

          Simon Chapman

          Margaret, yes of course. I hope you were not assuming that I somehow was suggesting that NASEM’s report was the last word we need on ecigs, and that all further research can now stop and policy be based on what we know or don’t know now. The NASEM report is just the best compilation of what we know now. I totally agree that ecigs “appear” to pose less risk that cigarettes. Our view of just how less risk risky will improve over time as we see longitudinal data on whether or not long term use causes problems. But it hardly follows from that that ecigs should be allowed to be used in areas where smoking is banned, the entire focus of my article.

          Reply
  2. 2

    Kate Sommerville

    Thanks for the article.

    For me, there are also concerns about the impact of nicotine on dopamine activity in the brain. https://www.psychologytoday.com/conditions/nicotine

    Why contribute to the development of compulsive behaviours in human beings for commercial profit of a few big companies like Phillip Morris who will undoubtedly supply the nicotine needed for vaping?

    Reply

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